Isabelle is well known in Australia for her portrayal of troubled teenager Vicki in the critically acclaimed Network Ten series Puberty Blues. Prior to joining the cast of Puberty Blues, Isabelle appeared in guest roles in Network Nine's Rescue Special Ops, ABC's popular teenage series Dance Academy, and an extended guest role in the Network Seven's long-running series Home & Away.
In 2017, Isabelle will also be seen in Australia Day, a feature-length drama directed by acclaimed film and television director Kriv Stenders, and produced by Foxtel and Emmy Award-winning producers Hoodlum.
Early 2017 saw Isabelle cast as the series regular Crystal in the highly-anticipated new series Marvel's Inhumans, for ABC in the U.S.
Isabelle's prior U.S. credits include the ABC pilot Sea of Fire, which chronicled the fallout from three teenage girls starring in a pornographic film, which tears their families apart and leads to a disappearance and a murder.