Andrew J. West was born in Merrillville, Indiana, and grew up in the nearby town of Lake Station. He was interested in acting from an early age, but didn't actually get to throw himself into the art until he attended Indiana University. Initially, he studied philosophy and anthropology, steering clear of the theatre department. However, that changed when he started auditioning for university plays and began landing roles, including the lead in Eric Bogosian's Suburbia. This marked a turning point in Andrew's life and he began writing, producing, and acting in short films with his college friends, several of which went to the festivals and won awards.

After moving to L.A., Andrew started securing roles, including the role of the young Christian Troy in the cult classic FX show Nip/Tuck. He had simultaneous recurring roles on Greek and Privileged, and landed guest-starring roles on hit shows such as Bones, CSI:NY, Ghost Whisperer, Castle and Body of Proof. Trying his hand at comedy, he landed the lead in the critically acclaimed web series Rockville, CA from Josh Schwartz. He also guest starred on Shit My Dad Says and Suburgatory, which led to the booking of lead roles in two network pilots: ABC's Who Gets the Parents opposite Jane Kaczmarek and Adam Arkin and Family Practice opposite Christopher Lloyd and Jean Smart.

Recently, Andrew shot the lead in the indie film Antiques, opposite Mary Steenburgen and Ashley Greene. Prior to that he shot the lead role opposite Jim O'Heir in the indie feature film The Middle Man, as well as the lead role in the Tom Kapinos/Warner Brothers pilot Dead People, and a two-episode guest starring role on NBC's Under The Dome. Andrew also appeared in a multi-episode arc on the highly acclaimed hit AMC series The Walking Dead as Gareth, the head of Terminus. He also shot the lead role in the indie film Walter, opposite William H. Macy.

He currently resides in Los Angeles.