Seth talks to Guest Host Ike Barinholtz about the first time they met, Ike embarrassing him when they were smoking pot with Paul McCartney at the SNL afterparty, shooting season two of The Studio, getting his first colonoscopy, his movie The Invite, filming sexy scenes with Penelope Cruz, and getting another Emmy nomination for The Muppet Show. Watch 'Jimmy Kimmel Live!' Weeknights 11:35/10:35c on ABC and Stream on Hulu.